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Adrenal extract

Last Updated on May 19, 2021 by MyFormulary

Related Terms

  • ACE, Adrena Support©, adrenal, adrenal complex, adrenal concentrate, adrenal cortex extract, adrenal factors, adrenal substance, glandular, protomorphogen (adrenal), suprarenal extract, whole adrenal extract.

Background

  • Adrenal extracts are derived from the adrenal glands of cows, pigs, or sheep gathered from slaughterhouses. The adrenal glands, which are above the kidneys, secrete adrenal hormones. The adrenal medulla secretes epinephrine (adrenaline) and norepinephrine (noradrenaline) while the adrenal cortex secretes a group of hormones called corticosteroids.
  • Adrenal extracts have been used medicinally since 1931, primarily in the injectable form. Today, adrenal extract is available only in the form of capsules or tablets. Commercially available adrenal extracts are made from the whole gland (whole or total adrenal extracts) or just from the outer part of the gland (adrenal cortex extracts). Although adrenal extract has been used to treat fatigue and low adrenal function, currently no human trials of adrenal extract have been performed to support these claims.

Evidence Table

    Disclaimer

    These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

*Key to grades:

Tradition

    Disclaimer

    The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

    Disclaimer

    The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

  • Adults (18 years and older)

    • There is no proven safe or effective dose for adrenal extract. Commercially available adrenal extracts are made from the whole gland (whole or total adrenal extracts) or just from the outer part of the gland (adrenal cortex extracts).
  • Children (younger than 18 years)

    • There is no proven safe or effective dose for adrenal extract in children.

Safety

    Disclaimer

    The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

  • Allergies

    • Avoid in individuals with a known allergy or hypersensitivity to adrenal extract.
  • Side Effects and Warnings

    • When taken by mouth, no adverse reactions have been reported. However, adrenal extracts are derived from raw cow, pig, or sheep adrenal glands, so there is concern about contamination with diseased animal parts. To date, no reports of disease transmission to humans due to use of contaminated adrenal extracts have been documented. Bovine spongiform encephalitis (BSE) has been reported in some countries, and adrenal extract products should be avoided in these areas.
    • Adrenal extract is likely unsafe when used parenterally. Use of injectable adrenal extract has been associated with serious bacterial infections and abscesses at injection sites, when contaminated with diseased animal parts. In 1996, the U.S. Food and Drug Administration (FDA) issued a nationwide alert regarding an injectable adrenal cortex extract after more than 50 cases of serious bacterial infections were reported.
    • Avoid in immunocompromised patients. Theoretically, adrenal extracts may increase the risk of infection, as the extracts might harbor pathogens. Injectable adrenal extract reportedly caused serious infections.
  • Pregnancy and Breastfeeding

    • Adrenal extract is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

Interactions

    Disclaimer

    Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

  • Interactions with Drugs

    • Insufficient available evidence.
  • Interactions with Herbs and Dietary Supplements

    • In theory, taking hypophysis extract with adrenal extract (cortine) may augment the preputial glands.
    • Adrenal extract might affect mineral metabolism.

Attribution

  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ().

Bibliography

    Disclaimer

    Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.

  • Constantopoulos G, Carpenter A, Satoh P, et al. Formation of isocaproaldehyde in the enzymatic cleavage of cholesterol side chain by adrenal extract. Biochemistry 1966;5(5):1650-1652.
    View Abstract
  • Fujii Y, Kato N, Kito J, et al. Experimental autoimmune adrenalitis: a murine model for Addison’s disease. Autoimmunity 1992;12(1):47-52.
    View Abstract
  • Grundy HM, Simpson SA, Tait JF. Isolation of a highly active mineralocorticoid from beef adrenal extract. Nature 5-10-1952;169(4306):795-796.
    View Abstract
  • Kooij R. Augmentor effect of hypophysis-extract and adrenal-extract (cortine) on the preputial glands of rats. Arch Int Pharmacodyn Ther 8-1-1953;94(4):475-482.
    View Abstract
  • Koritz SB, Hall PF. End-product inhibition of the conversion of cholesterol to pregnenolone in an adrenal extract. Biochemistry 1964;14:1298-1304.
    View Abstract
  • Mason HL, Mattox VR. Chromatographic fraction of beef adrenal extract. I. Isolation of aldosterone. J Biol Chem 1956;223(1):215-225.
    View Abstract
  • Mattox VR. Isolation of 19-hydroxy-11-desoxycorticosterone from beef adrenal extract. Mayo Clin Proc 5-4-1955;30(9):180-182.
    View Abstract
  • Mattox VR, Mason HL, Albert A. Isolation of a sodium-retaining substance from beef adrenal extract. Mayo Clin Proc 10-7-1953;28(20):569-576.
    View Abstract
  • Nagao Y. Viability of meiotic prophase spermatocytes of rats is facilitated in primary culture of dispersed testicular cells on collagen gel by supplementing epinephrine or norepinephrine: evidence that meiotic prophase spermatocytes complete meiotic divisions in vitro. In Vitro Cell Dev Biol 1989;25(12):1088-1098.
    View Abstract
  • Oberst BB. Exchange transfusion. I. Technic and use of adrenal extract as an adjunct to therapy. Nebr State Med J 1955;40(4):121-128.
    View Abstract
  • Schreiber V, Stepan J, Gregorova I, et al. Crossed digoxin immunoreactivity in chromatographic fractions of rat adrenal extract. Biochem Pharmacol 4-1-1981;30(7):805-806.
    View Abstract
  • Tait JF, Simpson SA, Grundy HM. The effect of adrenal extract on mineral metabolism. Lancet 1-19-1952;1(3):122-124.
    View Abstract
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